# References: software, hardware & monitoring > Selected projects: study software for a pharma group, effects hardware for large ad screens on Kurfürstendamm and billboard monitoring still running today. Source: https://1x1it.de/en/referenzen/ Since 2006 we have delivered software, hardware and integrations. A selection of projects, from clinical research to an advertising campaign on Kurfürstendamm. [Discuss a similar project](https://1x1it.de/en/kontakt/#anfrage) View the project log References B2B - **Projects:** 4 in detail - **Areas:** software, circuit boards, firmware, servers - **Evidence:** 2 scientific publications with co-authorship - **Status:** monitoring still in operation today ## Project log The projects at a glance. We do not name our clients. For detailed information, please contact us directly. | Year | Client | Work | Status | | since 2015 | International pharmaceutical group | 1x1-MedCare analysis software for clinical studies, two scientific publications with co-authorship | In operation | | 2023 | Large LED screen, Kurfürstendamm | Circuit board, firmware and installation for light and smoke effects for a streaming service’s campaign | Completed | | 2024 | Large LED screen, Kurfürstendamm | Steam effect from the advertising screen for a home appliance manufacturer’s campaign | Completed | | multi-year | Berlin outdoor advertising company | Lighting monitoring of advertising sites via GSM, alerts by call, text message and email | In operation | ## Study software for haemophilia research The publications were written together with haematologists and ultrasound specialists. The co-authorship of 1x1 IT-Solutions acknowledges our methodological and technical contribution. - **Client:** International pharmaceutical group - **Use:** Clinical studies - **Software:** 1x1-MedCare, developed in-house - **Method:** HEAD-US joint ultrasound - **Result:** Publication 2015, publication 2025 ### 1x1-MedCare: analysis of joint ultrasound according to HEAD-US - **Background:** In haemophilia, repeated joint bleeds lead to haemophilic arthropathy, progressive joint damage. The HEAD-US score (Haemophilia Early Arthropathy Detection with Ultrasound) detects this damage early by ultrasound and records it in a reproducible scoring system. Clinical studies need image processing, structured recording of findings and a longitudinal database that links scans to clinical endpoints. - **Our contribution:** Design, development and rollout of the complete analysis software Recording of findings according to the HEAD-US protocol: synovial hypertrophy, cartilage and bone damage, standardised per joint Patient and study database with history across treatment periods of several years Visualisations and reports on the effectiveness of new prophylaxis therapies Participation in the scientific analysis, which led to the co-authorship - **What the software does:** It records the HEAD-US score for all six major joints in three domains, keeps each patient’s ultrasound history over years and links findings to clinical endpoints for real-world evidence analyses. Comparisons between examiners stay reproducible, a requirement for clinical publications. - **Publications:** Publication 2015: first correlation of the standardised HEAD-US score with joint function in haemophilia patients. Publication 2025: real-world evidence report on a patient with haemophilia B, in whom ultrasound follow-up under a new prophylaxis shows that joint damage has stopped progressing. Both with co-authorship by 1x1 IT-Solutions. - **Method:** HEAD-US assesses elbows, knees and ankles and is now part of the EHC and ISTH guidelines for haemophilia care. Its strengths are reproducibility between examiners and suitability for follow-up over years. Disclosure: As part of the 2015 publication, fees and research funding from the client were disclosed. The scientific assessment is carried out independently according to the standards of the publication. Our contributions are technical in nature. ## Outdoor advertising in Berlin: effects hardware and monitoring For a Berlin outdoor advertising company we extended the large LED screen on Kurfürstendamm with real effects and monitored the lighting of its advertising sites. The circuit boards, firmware and servers are ours. - **Client:** Berlin outdoor advertising company - **Campaign:** Streaming service, new series season - **Location:** City West, Kurfürstendamm - **Live from:** 15 March 2023 - **Format:** Digital out-of-home ### Light and smoke from the advertising screen [Download video (MP4, 6 MB)](https://1x1it.de/assets/media/werbeflaeche-2023.mp4) Footage at the large LED screen in Berlin City West, March 2023. Video provided by the advertising company. - **Background:** For the launch of a new series season, the LED screen on Kurfürstendamm was not just to show images but to act as a stage: real light and smoke effects were to burst into the street scene at exactly the right moment, in sync with the animated spot. - **Task:** The advertising company’s playout platform controlled the spots centrally. What was missing was a bridge that sends precisely timed signals from playback to spotlights and fog machines, without touching the running system. Effect no more than a few milliseconds behind the spot Fail-safe over several weeks of campaign time Integration without a custom extension of the platform Control of all effects devices, expandable with further actuators - **Our contribution:** Circuit design, component selection and layout for continuous operation In-house manufacture of the circuit board, including assembly and housing Firmware that converts network signals to the actuators in real time Mounting at the large LED screen and wiring of the light and fog actuators Setting up the signal chain together with the platform’s support team Testing and acceptance during the running campaign - **Three-stage design:** The platform sends a signal when the spot starts. The 1x1-Bridge (our own circuit board and firmware) receives it and triggers the spotlights and fog machines frame-accurately. Depending on the environment, communication runs over UDP, MQTT or HTTP. Each stage stays replaceable, and failures stay limited to one stage. - **Client:** Berlin outdoor advertising company - **Campaign:** Home appliance manufacturer, product launch - **Location:** City West, Kurfürstendamm - **Period:** 2024 - **Format:** Digital out-of-home ### Steam from the coffee cup on the screen Photo at the Kurfürstendamm site, 2024. The effect is triggered frame-synchronously with the spot. - **Background:** For the launch of a new product line, the spot showed a coffee cup from which real steam was to rise into the city air, as if freshly brewed. - **Our contribution:** The 1x1-Bridge was used again, adapted to the fog actuators of this installation Exact signal sequences, so that the steam rises from the screen in sync with the spot Mounting at the large LED screen and wiring of the fog machine Connection to the platform’s running configuration, together with its support team - **Developed once, used many times:** The solution uses the same architecture as the 2023 project. The reusable 1x1-Bridge has thus run in campaigns for different brands. - **Client:** Berlin outdoor advertising company - **Application:** Lighting monitoring of advertising sites - **Transmission:** GSM/SMS, self-contained - **Alert:** Call, text message, email - **Status:** Still in operation today ### Billboard monitoring without cameras The system has been in continuous use for years and reports lighting faults in real time. Hardware, server and alerting are all in production. - **Problem:** Illuminated advertising sites are a contractual obligation after dark. If the light fails and is only noticed on the next inspection round, the advertising company loses hours to days of advertising impact and revenue. Cameras are ruled out in public spaces, because recording third parties without consent is not permitted under the GDPR and the BDSG (German Federal Data Protection Act). On top of that, the sites are spread across areas of the city without a network connection. - **Solution:** Each billboard has a monitoring box: our own circuit board with a GSM modem and sensors that measure only the lighting, not the surroundings. If the lighting fails, the box sends a text message to a central server. The server alerts the people responsible, depending on shift, time of day and location, by a call through the phone system, by text message or by email. A call does not get lost in the on-call inbox. Level 1: complete lighting failure, immediately critical Level 2: individual faulty lamps, prepared via OneWire brightness sensors for each lamp - **Our contribution:** Circuit design of the box with GSM modem and sensor connection In-house manufacture of the circuit boards, rugged housing for outdoor use Firmware with thresholds, self-monitoring and regular heartbeat signals Our own server software for analysis and multi-level alerting Connection to the client’s phone system for automatic alert calls Operation and maintenance over several years - **Why it is still running today:** GSM and SMS still get through when LTE or 5G data fails No cloud: the server is at the client’s premises, so no service can be discontinued under it Sensors, transmission, analysis and alerting are separate and can be replaced individually Without cameras, there are no follow-on data protection costs and no permit risks when sites change ## Three out of four projects start on the workbench. Our own circuit board, our own firmware, our own server: we build what is missing between systems and continue to look after it afterwards. More references will follow. For information on individual projects, please contact us directly. [View hardware development](https://1x1it.de/en/hardware-entwicklung-programmierung/) ## A similar project? Tell us what needs to be connected, measured or built. [0173 644 22 17](tel:+491736442217) [Discuss a similar project](https://1x1it.de/en/kontakt/#anfrage)